Association between Transcription Factor 7-like-2 Polymorphisms and Type 2 Diabetes Mellitus in a Ghanaian Population

Type 2 diabetes mellitus (T2DM) has been strongly associated with single nucleotide polymorphisms (SNPs) in the TCF7L2 gene. This study investigated association between rs12255372, rs7903146 gene and T2DM a Ghanaian population. A case-control design was used for this study. total of 106 patients 110 control participants were selected. Basic data collected included body mass index, blood pressure socio-demographics. Fasting samples processed for: serum lipid analysis, plasma glucose estimation HbA1c estimation. Parts whole DNA extraction using modified salting-out method. Common allele-specific primers designed genotyping Modified Tetra-Primer Amplification assay. Associations evaluated logistic regression models. The risk variant significantly 2.16 vs. 4.06 increased odds <60 years ≥60 years. Both rs12255372 women, overweight/obese, negative family history (T2DM-NFH) low-HDL-C. In multivariate model, but not 2.18, 5.01 2.25 T2DM, under codominant, recessive additive respectively (p < 0.05). is more highly subgroup—women those T2DM-NFH, yet who have cardiometabolic risk.